344 Kojima 



that the cells of the parath3^roid no longer have a compact appearance, but 

 are swollen, each containing a large vacuole. 



But occasionally this vacuolated appearance is observed in normal 

 animals, altiiough perhaps less marked than after thyroid feeding. It 

 must be questioned if it is a specific effect on the parathyroid. 



Admistration of Posterior Lobe of Pituitary. 



Changes in Thyroid. — Feeding with posterior lobe of ox-pituitary 

 has a remarkable effect on the epithelium cells of the thyroid vesicles. 



Fig. 5. — Section showing adjacent portions of thyroid and parathyroid of male rat to 

 which 0"2 c.c. of 1 per 1000 adrenalin solution was administered per diem during seven 

 days. Microphotogi-aph ; magnified 200 diameters. Hsmatoxylin-eosin preparation. 

 The thyroid vesicles are filled with a thin colloid staining faintly by eosin. The 

 epithelium cells are flattened, but much less so than with thyroid feeding. In some 

 vesicles certain of the epithelium cells are swollen, and the swelling projects towards 

 the colloid contents of the vesicle. The parathyroid has a loose open appearance : 

 this seems to be due to swelling and vacuolation of its cells. 



Their cytoplasm is very clear, with a sharp outline stained faintly by eosin. 

 They become more cubical, and acquire a swollen appearance : this gives 

 the cells a barrel-like appearance. The nuclei are shrunken, and are 

 uniformly stained by hfematoxylin : they lie nearly in the middle of the 

 cytoplasm. Many of the vesicles are empty of colloid. This, when present, 

 is stained very faintly by eosin. In some of the vesicles debris of cells is 

 seen mingled with a thin-lookinof colloid. 



Changes in Parathyroid. — All the cells of the parathyroid are 

 swollen, and the whole structure of the gland is loose, apparently as the 



