Studies on the Endocrine Glands 345 



result of fi'dematous swellincr. The nuclei, however, are shrunken, and 

 stain ilarkly with hematoxylin. 



Administration of Adrenalin. 



Chantjes in Thyroid. — Most of the cells of the vesicles are flattened. 

 The vesicles are full of colloid, staininjj a delicate pink colour with ha^ma- 

 toxylin and eosin. Althoufjh in considerable amount there is less colloid 

 than with thyroid feeding. It tends also to shrink more on fixation. 



Changes in Parathyroid. — Adrenalin seems to have much the same 

 etiect as posterior lobe of the pituitary upon the parathyroid, but the 

 cells themselves are not swollen — indeed, the cytoplasm may be shrunken. 

 All the cell-nuclei stain deeply with h?ematoxylin. 



Summary. 



1. Administration of thyroid and of sodium and potassium iodides 

 causes accumulation of colloid in the vesicles of the thyroid of rats. The 

 epithelial cells lining the vesicles are flattened. The cells of the parathyroid 

 are generally swollen. 



2. Administration of posterior lobe of pituitary gives the epithelial cells 

 of the thyroid a swollen, barrel-like appearance; their nuclei are shrunken. 

 The structure of the parathyroid becomes loose. Its cells are also swollen 

 and their nuclei shrunken. 



3. Administration of adrenalin causes somewhat similar changes in the 

 thyroid and parathyroid to those produced by posterior lobe of pituitary, 

 but they are less marked. 



BIBLIOGRAPHY, 



(1) Ballet and E.nriquez, La medecine moderne, 1895, civ., and Sem. med., 

 1895, 330. 



(2) Lanz, Deutsch. med. Wochenschr., 1895, No. 37. 



(3) Mediger, Dissert. Greifswald., 1895, cited by Peiser. 

 (■4) Geokgiewsky, Zeitschr. f. klin. Med., 1897, xxxiii. 153. 



(5) Cunningham, Journ. Exper. Med., 1898, ii. 



(6) GoNTSCHARNKOVv, Centralbl. f. allg. Path., etc., 1902, xii. 121. 



(7) Ghedini, Centralbl. f. Bakt., 1903, xxxiv. 721. 



(8) Peiser, Centralbl. f. allg. Path., etc., 1905, xvi. 513. 



(9) Chalmers Watson, Quart. Journ. Exper. Physiol., 1909, ii. 383. and 

 1912, 229. 



(10) Christiani, Compt. rend, de la soc. de bid., 1892, xliv. 798. 



(11) Erdhbim, Ziegler's Beitr., 1903, xxxiii. 158, and Mitt. a. d. Grenzgeb. d. 

 Med. u. Cliir., 1906, xvi. 632. 



