356 Kojima 



of the parathyroid, is difficult to say. In C group the amount of food 

 consumed remained much less than in A and B groups. The two animals 

 of C group (thyroidectomy), which died during the lifth and sixth weeks 

 respectively, did not appear to be ill, and took their food as well as the 

 others until a few hours before death. 



During the seventh and eighth weeks, which was the period of meat 

 and rusk feeding, the amount of food consumed by B group (parathyroid- 

 ectomy) diminished, while that of A and C groups remained much as it 

 was before and after. When thyroid feeding was commenced the amount 

 of food consumed diminished in all three groups : as a result the amount 

 of nitrogen taken in was far less than before (Chart 2). During para- 

 thyroid feeding the amount of food was increased in all, and the intake 

 of nitrogen also was therefore increased. Since, however, the commence- 

 ment of j)arathyroid feeding corresponded with the cessation of thyroid 

 feeding, it may well be that the increased appetite was rather the result of 

 the latter than of the former ; in fact, it will be seen later in Series II. 

 that parathyroid feeding does not itself appear to increase the appetite. 

 During the period of feeding with combined meat and rusks (seventh and 

 eighth weeks) there is, as might be expected, a large increase in the amount 

 of nitrogen taken in in all animals ; during it the animals of C group 

 (thyroidectomy) showed no marked differences as regards the amount of 

 nitrogen taken in as compared with Groups A and B. But during the 

 period of thyroid feeding the amount of nitrogen taken in was far less in 

 Groups B and C than in Group A. Two rats of Group A, however, died, 

 apparenth^ as the result of thyroid feeding ; post-mortem there was con- 

 siderable congestion of the intestines. The state of the heart was not 

 noted, but Herring (3-1) has recently shown that sudden death is liable 

 to occur in thyroid-fed rats, and that the heart in such animals becomes 

 greatly hypertrophied. We may assume that these two (unoperated) rats 

 were particularly susceptible to thyroid, while those which survived offered 

 stronger resistance to it. In Groups A and B (normal and parathyroid- 

 ectomised) no marked changes are noted in the amount of nitrogen in the 

 urine up to the seventh week, while C group (thj^roidectomised) shows a 

 remarkable decrease. When meat was added to the diet a large amount 

 of nitrogen appeared in the urine of all the groups, obviously due to the 

 addition. During the thyroid feedino^ the amount of nitrogen in the urine 

 showed diminution in all the groups, but this was especially marked in B 

 and C. During parathyroid feeding, on the other hand, the amount of 

 nitrogen increased in Groups B and C, while in A group there was, if 

 anything, a little decrease (Chart 3). 



With regard to the amount of nitrogen retained in the body, in the 

 animals of Group B there was less nitrogen retained during the second 

 week, which might well have been due to the direct result of the operation 

 (parathyroidectomy), but on recoverj^^ from the immediate results of the 

 operation nitrogen retention was increased. In C group (thyroidectomy) 



