Studies oil the Endocrino (Hands 359 



thyroid fcediiii;. After ten days' thyroid feedin<jj an increase of COg output 

 was apparent in the males, but a sli<jlit diminution in the females (Chart 13). 

 These results appear to contradict those of Cramer and M'Call, but there 

 are not unlikely to be ditlerences in susceptibility to thyroid feedinc; in 

 ditierent animals. 



Fifth Series. After Castration. — Twenty-two days and forty-eiglit 

 days respectively after the operation the gaseous metabolism was investi- 

 gated, tirst, in four, and, second, in two full-grown castrated male rats, and 

 simultaneously in as many "entire" controls. All the castrated animals 

 showed a marked diminution of CO2 output, which continued up to forty- 

 eight days after the operation (Tables XII. and XIII., Chart 14). In all the 

 castrated animals the appetite and weight increased. 



It was noticed post-mortem that adipose tissue was remarkably developed 

 in the subcutaneous tissue and at the back of the mesentery. 



SUM.MAUV. 



1. Thyroidectomy in rats produces a diminution both of nitrogen and 

 of calcium output. 



2. After parathyroidectomy in rats there seems to be an increase of 

 calcium in the urine, and less is retained in the body, but nitrogenous meta- 

 bolism shows no definite change. 



3. Thyroid feeding produces a decrease in body-weight and a diminu- 

 tion of nitrogen and gaseous metabolism in all the animals, whether normal, 

 thyroidectomised, or parathyroidectomised. 



4. Castration is attended in male rats by diminution of CO2 output. 



BIBLIOGRAPHY. 



(1) RovixsKY, cited in Zentralbl. d. exper. Med., 1914, 618. 



(2) Schneider, Diss. St Petersburg. Cited in Biedl's Innere Sekretion, 1916, 

 Teili. S. 196. 



(3) Mannsfeld and Mijlleb, Pfliiger's Arch., 1912, cxliii. 157. 



(4) IsELix, Deutsch. Zeitsclir. f. Cliir., 1908, xciii. 494. 



(5) Erdhboi, Frankf. Zeitschr. f. Path. 1911, vii. 175, 238. 



(6) HoHLBAUM, Ziegler's Beitr., 1912, liii. 



(7) ToYOFUKU, Frankf. Zeitschr. f. Path., 1911, vii. 249. 



(8) MoRBL, Compt. rend, de la soc. de biol., 1910, Ixviii. and Ixx. 780. 



(9) M'Cai.lum and Yoegtlin, Johns Hopkins Hosp. Bull., 1908, xix. 91, and 

 Journ. Exper. Med., 1909, xi. 118. 



(10) Cooke, Journ. Exper. Med., 1910, xii. 45. 



(10a) Noel Patox, Quart. Journ. Exper. Pliysiol., 1917, x. 



(11) Greenwald, Amer. Journ. Physiol., 1911, xxxviii. 103. 



(12) Cooke, Journ. Exper. Med., 1911, xiii. 439. 



