28 SMALL roX IN SIIKK.l'. 



Sept. 17. — The redness of the integument is less 

 perceptible to-day than yesterday, and the animal's 

 ♦general heidth remains nearly the same. Papulae are 

 forming. 



Sept. 18. — The papulje have become more nume- 

 rous, also more elevated, and of a deeper red colour. 



Sept. 20. — Imperfectly formed vesicles cover the 

 whole surface of many of the papula}, giving them a 

 blanched appearance. Some of the smaller vesicles 

 are roinided at their summits, but the gi'eater number 

 are flat, with slightly raised margins, but no distinct 

 areola surrounds them. The patient's health has im- 

 proved, and the appetite is returning. 



Sept. 21. — The cuticular covering of many of the 

 less developed papula has assumed a brown colour, 

 indicative of approaching desquamation ; and a still 

 greater number of these elevations have presented 

 themselves on the inner part of the arms. 



To-day the animal was seen by Mr. Ceely, of Ayles- 

 bury, who has given to the subject of vaccination much 

 attention, and he at once recognised the variolous 

 character of the disease. Being anxious to carry on 

 some experiments with the ovine lymph, several points 

 were charged by him fi-om the vesicles. 



Sept. 22. — Some of the papuloe are disappearing 

 without passing through the several stages; others 

 have their surfaces still covered with small vesicles. 

 The cuticle is of a browner colour upon the earliest 

 formed, being detached in scabs, but no pus is disco- 

 verable beneath it. 



It should be here mentioned that Mr. Marson, Sur- 

 geon to the Small-Pox Hospital, who had taken a lively 

 interest in this case, and watched its progress daily. 



