38 SMALL-rox IN sin: IT. 



Oct. 2. — A slight infiamniatory blush is the only 

 trace of the inoculation. The effects have been simply 

 local, and the animal's general health seems not to 

 have suffered throughout the progress of the changes 

 produced by the operation. 



In this case we have evidence that, when the local 

 inflammation is accompanied with the early formation 

 of vesicles or pustules, such a circumstance is to be 

 resrarded as unfavourable to the success of ovination. 

 Many of the failures of vaccination in the human sub- 

 ject may probably be attributed to the same cause ; 

 for it appears that if the hjmph quickly excites inflam- 

 matory action in the vessels of the papulated surface 

 of the dermis, it is likely to become mingled with the 

 exudations which fill the vesicles that are produced by 

 such inflammation ; and, consequently, it is thrown off, 

 either by the immediate bursting of these vesicles, or 

 by the drying up of their contents, and their subse- 

 quent rejection with the cuticle in the form of a scab. 



Although the positive conveyance of the lymph into 

 the circulation within a short space of time after it is 

 placed under the epidermis may not be absolutely 

 necessary to produce, first, its local and ultimately its 

 constitutional effects, still the corded state of the ab- 

 sorbents which follows a successful ovination proves 

 that it has caused a morbid condition of those vessels ; 

 and this is accompanied by a peculiar inflammatory 

 action of the part, ending in the exudation of a fluid 

 that has the same properties as that employed in the 

 operation. It therefore appears that the virus or fluid 

 used for ovine inoculation should excite its more imme- 

 diate and irritative effects on the lymphatics, and not 



