40 SMALL- pox IN SIIKKP. 



Oct. 15.— With the exception of two small papulae 

 having appeared on the brisket, there is but little change 

 in either the general or local symptoms. 



Oct, l6._The fever is less, and the patient feeds a 



little. 



Oct. 17.— The skin at the corner of the mouth is 

 cracked, and the sore looks unhealthy. Vesicles have 

 formed on the papulae on the lip, but those on the 

 brisket are unaltered. 



Oct. 19. — The vesicles have accidentally been broken, 

 and brownish scabs cover the sores. There is ulcera- 

 tion of the skin, with a tendency to spread at the angle 

 of the mouth. The patient's general health is much 

 improved. 



Oct. 23. — Every day since the last report the ulcer 

 has been dressed with diluted chloride of zinc; and 

 healthy granulations are beginning to form. 



Oct. 25.— The animal may be reported convalescent. 

 The papulae on the brisket have disappeared without 

 proceeding to vesication. 



This proved to be another instance of natural 

 variola ovina, assuming a mild form ; a fact, perhaps, 

 to be accounted for by the shortness of the time this 

 animal, as also the subject of our first experiment, was 

 allowed to remain with an infected sheep. The daily 

 progress of the disease was watched with more than 

 ordinary anxiety ; for as yet we had succeeded only in 

 one instance in procuring fluid from the eruptive vesicles 

 of a sheep in which the constitutional and local symp- 

 toms of variola were not aggravated ; and it is from 

 such cases that the lymph should be selected for ovina- 

 tion. We regret, therefore, that the accidental rupture 

 of the vesicles on the second day of their formation 



