ITS PAl'ULAll STAGK. 75 



are punctured, a resistance is found to the passage of 

 the needle through them. Instead of a lymphatic 

 humour exuding from the punctures, a drop of blood 

 only escapes*." 



We have noticed in both natural and inoculated 

 small-pox of the sheep a diffused redness of the integu- 

 ment occurring in patches of various size, and preceding 

 for a day or two the formation of the papuke. In ino- 

 culated cases this redness is frequently so well marked, 

 that it constitutes a disease of the skin analogous to 

 roseola variolosa of the human subject, and establishes 

 another similarity between these maladies. A reference 

 to our experiments 1, 2, and 3, will shew that it was 

 present in each of these instances ; becoming less visible 

 as the papulas were developed, and subsiding altogether 

 after they were perfected. 



The duration of the papular stage of ovine variola is 

 found to vary ; we have seen vesicles produced on the 

 nodules on the second day of their appearance, and we 

 have known six days to elapse without vesication 

 taking place. We consider that, in the majority of 

 instances, three days may he regarded as the period of 

 papulation; it being generally longer in confluent variola 

 than in distinct. Hurtrel d'Arboval speaks of the occa- 

 sional disappearance of the papulated eruption, and of 

 its remaining dormant in the system for three weeks, 

 and then breaking outf . Cases of this kind have not 

 come to our knowledge, but we will not doubt the accu- 

 racy of such an authority. 



Simultaneously \\\i\\ the first indications of the inte- 



* Trattato di Vaccinazione, del Dottore Luigi Sacco. Milano, 

 1809, p. 149. 

 t Article Clavelee. 



