108 SMALL-rOX IN SIIKKP. 



Oct. 27. — The inflamed spots have increased in 

 size, and are painful on pressure. 



Oct. 28.— The ulcer alluded to on the 26th has 

 assumed a health}^ condition. The other incisions are 

 more inflamed, and a red speck or stigma has appeared 

 about an inch from the circumference of one of these 

 places. 



Oct. 29.— Eighth day of hioculation. The patient's 

 health is afl'ected, the pulse and respiration are hurried, 

 and the appetite is impaired. The inoculated spots 

 and the stigma are altered in colour, being changed 

 from a deep red to a reddish yellow ; their centres are 

 also depressed, and they are encircled by an elevated 

 border of lighter colour than the contiguous skin. 

 The surfiice of the body is hot, and small isolated 

 patches of a pink hue are present on the inner parts of 

 the arms and thighs : this eruption is probably a mo- 

 dified form of roseola variolosa.— /See the figure in 



'plaie 5. 



Oct. 30. — The constitutional symptoms have under- 

 cone but little chancre. The efflorescence is more 

 diffuse, and papulae can be felt deeply embedded m 

 the dermis. 



Oct. 31.— Tenth day. Both the general and local 

 appearances indicate a favourable termination : papulas 

 are developed, which are distinct from each other. A 

 peculiar alteration has taken place on the ovinated 

 places ; a number of minute vesicles, aiTanged in a cir- 

 cular order, exists within the outer ring or elevated 

 border previously described ; a representation of this is 

 also given in jjlate 5. 



jVoy. 3. — Thirteenth day. Each inoculated spot is 

 now covered with a large patch of whitened cuticle, 



