INOCUI-ATION. Ill 



Oct. 29. — The inflaniniation surrounding the punc- 

 ture is increased. The animal was seen by Mr. JNlar- 

 son, who agrees that the appearances are specific. 



Nov. 1. — A rose-coloured efHorescence covers both 

 the hairy and nude parts of the body : it is particularly 

 manifest on the teats and under-surface of the tail. 

 None of the other incisions have taken. 



Nov. 2. — The rash has extended, and is of a deeper 

 colour. Very little constitutional disturbance is pre- 

 sent. 



Nov. 3. — Less diffused redness exists, but many 

 well-defined stigmata, which are nearly circular in 

 shape, stud the skin of the udder, labia, and anus. 

 Papulae can be felt. The ovinated spot is highly in- 

 flamed, but it does not shew any central depression. 



Nov. 4. — Fourteenth day of inoculation. Papulaj 

 are formed. The stigmata arejlat on the surface, but 

 bounded by elevated margins. The patient has but 

 little fever. 



Nov. 5. — Some of the stigmata have disappeared. 

 The papulae are considerably increased in number, but 

 perfectly distinct. 



Nov. 6. — Both the constitutional and local symptoms 

 are unaltered. 



Nov. 7. — Considerable fever is present; more pa- 

 pulae have shewn themselves; those first developed are 

 much enlarged. No stigmata can now be detected. 



Nov. 8. — Symptoms aggravated. Papulos coufiaent 

 on the inferior parts of the abdomen and inside the 

 arms ; disi'inct on other parts. 



Nov. 9. — Patient very ill : the lips, nostrils, sides of 

 the face, and eyelids are much swollen ; conjunctiva 



