lis S.MALL-POX IN SllKKP. 



twelfth or thirteenth day of oviiiation ; and occasion- 

 ally we have had to wait even longer than this. One 

 of the most remarkable instances of protracted vesica- 

 tion coming under om' immediate notice, is that which 

 we have recorded at page 110 & seq., where we did not 

 succeed in charging points until the twenty-third day ; 

 and even then the su})ply of the fluid was scanty, and 

 its quality very impure. It is, however, to be borne in 

 mind, that an irregularity in the progi-ess of variola is 

 always connected with the confluent variety of the dis- 

 order, whether it arises from natural or artificial causes, 

 and that such cases rarely produce a limpid ichor. 



The continental authorities assert, that the \irus may 

 be obtained from inoculated animals on the eighth or 

 ninth day. But should we be right in the conjecture 

 that these dates have reference to the time at which 

 the inflammation first takes place in the punctures, and 

 not to the period when the operation was performed, 

 then there is only a seeming not a real difference in 

 the statements. Mr. Ceely informs us, that he has 

 seldom been able to obtain lymph before the twelfth 

 day : and in a note received from him when our ex- 

 periments were being carried out, he gives the follow- 

 ing particulars relative to the subject : — " On the fourth 

 day succeeding the inoculation of the animal which 

 yielded the ichor now sent, there were febrile symptoms, 

 and roseola and stigmata near the inoculated parts, 

 which were hard, elevated, and of a brick-red colour. 

 The general and local symptoms increased, and on the 

 sixth and seventh day of inoculation large papulae ap- 

 peared, chiefly in the vicinity of the punctures. Sub- 

 se(piently ])apulte shewed themselves near the mouth, 

 and eventually the absorbents in the groin, near to the 



