r20 SMALL roX IN' SIIKKl'. 



turl)i(l cDiitcnts of declining vesicles to communicate 

 the disease, the following experiment was instituted : — 



Nor. 29. — An Irish sheep was inoculated; small 

 punctures were made on the sides of the sternum and 

 inner part of each thigh, and into these some n/'///,// 

 fluid taken from the eruptive vesicles of a sheep that 

 had been ovinated nineteen days before was inserted. 

 The animal which yielded the lymph had experienced 

 a mild attack of the small-pox. 



Dec. 2. — Three of the incisions give proofs of the 

 existence of the variolous poison. 



Dec. 3. — Local symptoms increasing. 



j)pc. 1. — Sijcth day of inoculation. Papulae are 

 forming on the breast. Two stigmata are present 

 near to the inoculated places. 



Dec. 6. — The eruption is very slight. The malady 

 is progressing favourably, and the patient's health is 

 but little disturbed. 



j)ec. 8.— Most of the papulae are vesicated, others 

 are diminished in size. The punctures are still of a 

 deep red colour, and painful. The stigmata are cup- 

 shaped, and the absorbents corded. 



Dec. 10. — The contents of the vesicles have an opa- 

 hne appearance ; the stigmata are less visible, but the 

 suppurative action has commenced on the edges of the 

 inflamed spots surrounding the punctures. 



Dec. 12.— The cuticle is desquamating in brown 

 scabs from the vesicles, and in furfuraceous scales from 

 the papulae, which did not go on to vesication. The 

 ulcerative process is established in the inoculated parts, 

 associated with greater inflammation of the absorbents. 



Dec. 14. — Ulceration has extended to the subcu- 

 taneous tissue, and large sloughs are being detached. 



