OVINATION AFTKU VACCINA'lION. 143 



liavity may not be referrible to the special arrange- 

 ment of the organism of the integument : the constancy 

 of it," he says, "justifies this conjecture*." The mean- 

 ing which we would attach to the expression, " erup- 

 tion of the pustules," is not that vaccination of sheep is 

 attended with a general eruption, but that the local 

 effects of the vaccine are similar to those which are 

 caused by the ovine lymph. And we come to this con- 

 clusion from the circumstance, that the same terms are 

 employed by the French in their descriptions of the 

 ovinated places ; and because the ichor of cow-pox very 

 seldom produces any inflammatory action except on 

 the site of the punctures. 



" Variola vaccinia," INIr. Ceely observes, " is much 

 modified in the sheep ; it quickly passes through the 

 several stages : lymph forms by the fifth or sixth day, 

 and on the eighth the affection terminates. It differs 

 altogether from the vaccine of man, or the cow." The 

 peculiarities here mentioned we have witnessed in every 

 case of vaccination when satisfactorily performed ; in 

 illustration of which we insert two experiments of the 

 kind, which will likewise shew that the vaccine disease 

 did not render the sheep insusceptible to the action of 

 the ovine virus. 



Jan. 20, 1848. — Two sheep were vaccinated with 

 fresh fluid lymph, furnished by Mr. Marson : six punc- 

 tures were made in one animal, two on the inside of 

 each thigh, and one on either side of the sternum. In 

 the other, four incisions only were used for the insertion 

 of the lymph. 



Fifth day of vaccination : In the last named sheep, 

 the disease has taken in all the punctures, but only in 



* Trattato di Vaccinazione, p. 146 & seq. 



