146 SMALL roX IN SlIKKl'. 



diffused ivd-coloured eruption continues, but no papulae 

 can be detected. 



Tliirteenth day. — The skin has regained its normal 

 condition, with the exception of the places of inocu- 

 lation, which are covered by blanched epidermis, but 

 no lymph can be collected from beneath it. 



Twenty-second day.- -Since the last report the cu- 

 ticle has been desquamated in scabs of a dark brown 

 colour : the exposed sores are fast healing. 



These experiments, to a certain extent, confirm the 

 statement of D'Arboval, that the vaccination of sheep 

 cannot be depended on as a prophylactic ; and they 

 invalidate Sacco's opinion, that " vaccination is equally 

 as beneficial as ovination." We agree with the first 

 named author; for in no instance in our experience 

 has any variolous inflammation been produced by a 

 re-inoculation, although this has been frequently re- 

 peated. It is also worthy of observ^ation, that the 

 lymph which was used in the above cases did not 

 appear to be deteriorated by keeping, a circumstance 

 which clearly shews that the experiment recorded at 

 page 37-8 did not fail from such a cause, but probably 

 from the insusceptibility of the animal to its action. 



The near approximation in the nature of varioloid 

 diseases, and the fact that they sometimes can be con- 

 veyed from man to the lower animals, and vice versa, 

 determined us to inoculate several sheep with t/ie vines 

 of human smaU-iwx, that we might investigate the points 

 of resemblance, or any differences in the development 

 or progress of the malady. Our thanks are due to 

 Mr. M arson for supplying the virus and assisting in 

 the experiments; notwithstanding w^e have hitherto 



