148 SMAM.-l'oX IN SlIKKP. 



covered that, by inoculating the cow with small-pox 

 from the human body, fine active vaccine virus is pro- 

 duced.' M. Viborg, of Berlin, is reported to have ino- 

 culated cattle, and several other classes of domestic 

 animals, with success. 



" Mr. Ceely instituted a series of experiments on 

 the inoculation of the cow with variolous lymph in the 

 month of February, 1839. In his first subject no 

 effect was observed for nine days ; at the end of which 

 time, one out of seven punctures inoculated with virus 

 of the seventh or eighth day, presented the appearance 

 of a tubercle. On the tenth day, this tubercle had all 

 the characters of the vaccine vesicle ; by the fifteenth 

 day the vesicle reached its acme, and was ' truly splen- 

 did.' Decline commenced on the sixteenth day, the 

 crust was well formed on the seventeenth, but was 

 rubbed off prematurely. In this experiment the vesicle 

 was retarded five days ; the usual period of maximum 

 development of the variolo-vaccine pock being the tenth 

 day. In a second experiment, the first inoculation 

 failed. After re-inoculation, four out of the seven 

 punctures looked purplish or livid on the fifth day, and 

 were vesicular, with incipient central crusts on the sixth. 

 By the tenth day they had attained their acme. On 

 the eleventh, decline had commenced, and progressed 

 gradually, till the twenty-sixth day, when the crusts 

 fell, leaving behind them smooth rose-coloured pits*." 



This method of procuring a new lymph for vaccina- 

 tion has had many advocates ; but in consequence of 

 the failure of often-repeated experiments, it has been 

 nearly, if not entirely, abandoned. Besides which, ex- 

 perience has demonstrated that until the variolo-vaccine 



* Diseases of the Skiu, p. 77 & seq. 



