VAKIOI.Al'loN FOLLOWKI) BY OVINATION. 149 



lymph has undergone several removes, it does not take 

 freely, nor does the disease produced by it pass with 

 regularity through the respective stages. It requires, 

 therefore, to be assimilated by the tissues, or to become 

 humanized, before it can be depended on for vaccina- 

 tion. For similar reasons, we are of opinion, that 

 neither the variolation nor the vaccination of sheep 

 can be relied upon for yielding a fresh supply of lymph, 

 although Sacco speaks of the advantageous employ- 

 ment of vaccine lymph " regenerated" in the system of 

 the sheep. 



Whether the product of the natural ovi7ie vesicle 

 can be substituted for the vaccine, is a vexed question, 

 on which we will presently make some comments, prior 

 to which we shall insert the details of a case of small- 

 jwx inoculation, succeeded by ovination. 



]^ov. 10. — An Iiish sheep was inoculated with the 

 virus of the small-pox of the human subject, six punc- 

 tures being made in different parts, into which the 

 matter was inserted in a fluid state. 



Third day of variolation. — The incisions are more 

 inflamed than would be the case if the skin had been 

 simply punctured, but no specific effects are produced. 



Sixth day. — The inflammation has subsided, and the 

 site of the wounds can scarcely be detected. We there- 

 fore ovinaied the patient, using for the purpose some 

 points charged with impure lymph procured from a 

 case of confluent variola following inoculation. See 

 page 112, Nov. 15. 



Third day of ovination. — Three of the places have 

 taken : all symptoms of the pre\ious operation have 

 passed off*. 



Fifth day. — One incision on the side of the sternum 



