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is much more inflamed than the others ; two stigmata 

 have formed near it, and the contiguous absorl)ents are 

 enlarcred and corded. The animal is dull, and takes 

 but little food. 



Sixth day.— All the symptoms are aggravated, and 

 papuke can be felt deeply located in the dermis. 



Seventh day. — Papulae more perfected, but distinct. 

 The inflannnation on the brisket has extended so as to 

 join the stigmata; the swelhng is more, the pain on 

 pressure greater, but the redness less than ordinary. 



Ninth day.— The ovinated places are vesicular, with 

 the exception of the one before mentioned : the erup- 

 tion has undergone very little change, but the general 

 febrile action is diminished. 



Eleventh day. — Some of the papula? have disap- 

 peared; the inoculated vesicles are distended with 

 Umpid fluid, and pus is forming on the edge of the in- 

 flamed spot on the breast. 



Thirteenth day. — Suppuration steadily increases; 

 the epidermoid covering of many of the papula is 

 blanched and elevated, but no fluid can be collected 

 from beneath it. The animal's health is much im- 

 proved. 



Fifteenth day. — Ulceration of the skin of the breast 

 has commenced; the ovinated vesicles are turbid: the 

 eruptive vesicles being more fully matured, we charged 

 some points fi'om them for immediate use, but the 

 lymph was impure. 



Twentieth day. — Brown crusts of cuticle are de- 

 squamating from the papulae. The suppurative action 

 is going on in the punctures, and a large slough is 

 separating fi*om the brisket. 



Twenty-second day. — The ovinated places are all 



