186 A MANUAL OF BACTERIOLOGY 



muscles of the face being drawn and restless, and 

 gradually this expression amounts to one of actual 

 terror or horror. On the second or third day the 

 patient becomes much more excited, is restless in 

 every sense of the word, and a very peculiar feature 

 is that he has a characteristic habit of giving a 

 suspicious side-glance as though constantly looking 

 out for some hidden danger; then as the fever 

 advances a rambling delirium supervenes ; the 

 thirst increases, but along with this there is great 

 difficulty in swallowing especially fluids and 

 after making one or two attempts to swallow, the 

 very sight of water suggests such horrors that, 

 thirsty as the patient is, he is anxious to avoid it. 

 Then muscular tremors are noted ; these become 

 more and more marked, and violent spasms are 

 easily stimulated, as in tetanus. A sharp sound, a 

 touch, a bright light, or even a breath of air, may 

 give rise to violent muscular convulsions, and 

 eventually the patient is slowly suffocated as in 

 tetanus' (Woodhead). Such are some of the tor- 

 turing symptoms of hydrophobia. But it may be 

 stated that the symptoms are varied, depending 

 upon the nature of the region in the nervous 

 system encephalon or spinal cord where the 

 virus locates itself. The virus is found in every 

 part of the encephalon. Although the saliva of 

 rabid animals is virulent, it is not used by Pasteur 

 in his prophylactic treatment, the reason being that, 

 as saliva contains various microbes, it may give rise 

 to septic poisoning, etc., as well as rabies. There- 

 fore Pasteur has recourse to the central nervous 



