INFECTIOUS DISEASES AND MICROBES, ETC. 217 



in rabbits it reproduces malarial fever, with all its 

 characteristic symptoms, the threads and spores of 

 the bacilli being found in abundance both in the 

 spleen and the marrow. This microbe grows also 

 on albumin, urine, and other media in the presence 

 of air, and at a temperature of about 20 C. B. 

 malaria was originally discovered in the soil of the 

 Roman Campagna, and Antonio Ceci 1 obtained pure 

 cultures of the microbe from this soil. When these 

 pure cultures were inoculated in animals they pro- 

 duced malaria or intermittent fever. 



Dr. B. Schiavuzzi 2 has confirmed Klebs and Tom- 

 rnasi-Crudeli's discovery of Bacillus malarice, and 

 that it is the real cause (directly or indirectly) of 

 malaria. Cohn 3 has also verified the work of the 

 Italian bacteriologists. 



On the other hand, Laveran, 4 Richard, 5 Marchia- 

 fava and Celli, 6 Golgi, 7 Evans, 8 and others have dis- 

 covered certain organisms allied to the Flagellata in 

 the blood of patients suffering from malaria. These 

 organisms have been called Plasmodium malarice, 

 and they are said to give rise to intermittent fever 

 in man after intravenous injection. The blood cor- 

 puscles of a person so infected again contain the 

 plasmodia ; and it is further stated that these or- 

 ganisms alter the composition of the blood. 



1 See Professor Giglioli's Fermenti e Microbi, p. 592. 



2 Atti della R. Accademia dei Lincei, 1886. 



3 Beitrage zur Biologic der Pflanzen, 1886, p. 245. 



4 Comptes Rendus, 1881-2. 5 Ibid. 1882. 



6 Annali di Agricoltura (Roma), 1886, p. 4. 



7 Archivioper h Scienze Mediche, vol. x. (1886), p. 109. 



8 Proceedings of Royal Society, 1891. 



