228 A MANUAL OF BACTERIOLOGY 



but, unlike Koch's bacillus, they will not grow in 

 10 per cent, gelatine, (h) Lingard found two kinds 

 of comma-shaped bacilli in a case of noma, the 

 smaller of which is said to have been similar to the 

 choleraic one. (i) Gamaleia's bacillus was found 

 in a fatal fowl disease which was prevalent at 

 Odessa, (j) Weibel found various forms in mucus, 

 but their mode of growth is distinct. 



Koch's Spirillum cholerce Asiatics is always 

 present in Asiatic or malignant cholera, and it has 

 not been found apart from this disease, and dis- 

 appears from the body with the disease. Its habitat 

 is the intestinal canal, and the detection of this 

 bacillus enables the physician more readily to 

 diagnose the earliest cases in an epidemic of cholera. 

 Ermengem, 1 Watson Cheyne, 2 Koch, 3 Nicati and 

 Kietsch, 4 Macleod and Milles, 5 and others, have 

 produced the disease in dogs and guinea-pigs by 

 inoculation with pure sub-cultures of Koch's comma 

 bacillus. The last two investigators have arrived 

 at the following conclusions concerning cholera and 

 its microbe : 



(a) The comma bacillus (Koch's) is always 

 present and associated with certain changes in the 

 small intestine in cases of Asiatic cholera. (&) 

 There is no evidence to show that it is a normal 

 inhabitant of the human alimentary canal, and 



1 Recherches sur le Microbe du GhoUra Asiatique (1885). 



2 British Medical Journal, 1885. 



3 ' Etiology of Cholera ' in Laycock's Microparasites and 

 Disease. 



4 Revue d' Hygiene, 1885 ; Archives de Physiologic, 1885. 



5 Loc. cit., pp. 18-35. 



