CONNECTIVE TISSUE CABTILAGE BONE 



FlG. 60. PlGMENTED CELLS FROM THE 



CHOROID COAT OF THE Ox's EYE. 



Unstained; hence, only the pigment 

 granules appear in the figure. 1, gran- 

 ules contained within the cytoplasm ; 2, 

 free granules which have escaped from 

 cells injured during the process of teas- 

 ing; 3, the non-pigment ed nuclei. 



less flattened and are often closely applied to, or even wrapped around, 

 the fiber bundles. These lamellar cells have a small nucleus, a consider- 

 able rim of cytoplasm, which fre- 

 quently has a shrunken appearance, 

 and sometimes a few short cytoplas- 

 mic processes. The branching stel- 



.- r - . late forms, however, are characteris- 



y * '^jfeg& . tic of the younger connective tissues. 



ffi$f3 In certain locations a deposit of 



pigment granules occurs within the 

 connective tissue cells. Such pig- 



""^BterfS^". ' .'*..! ment .cells are usually found where 

 B\. protection against light seems desir- 



able, and are most abundant in the 

 choroid coat and iris of the eye. 

 The pigment granules are entirely 

 confined to the cytoplasm of the 

 cell ; the nucleus is never invaded by 

 the deposit. These granules belong 

 to the melanin series of pigments. 

 The cytoplasm of certain cells found in connective tissue contains 

 coarse basophil granules, which stain with dahlia and similar basic 

 dyes. This type is known as lasophil granule cells, 

 or mast cells (Mastzellen of the German authors). 

 The granules of other granulocytes are readily stained 

 with acid dyes, such as eosin (eosinopliil, acidopliil 

 or oxyphil granulocytes). According to the observa- 

 tions of H. B. Shaw (Jour. Anat. and Physiol., 

 1901), certain of the granule cells abound in those 

 locations where fat is deposited, and have a special 

 relation to the development of the fat cells of adipose 

 tissue. These granulocytes of fibro-elastic connective 

 tissue are apparently identical with those of the blood. 

 Lymphocytes and phagocytic leukocytes are also pres- 

 ent in connective tissue. 



It is a disputed point whether the granulocytes of 

 connective tissue differentiate from fibroblasts or 

 from lymphocytes ; the weight of evidence seems to incline to the latter 

 position. Plasma cells seem more probably altered fibroblasts but have 

 also been regarded by some as lymphocyte derivatives. The so-called 



FIG. 61. GRANULE 

 CELLS FROM THE 

 FIBROUS CON- 

 NECTIVE TISSUE 

 OF THE HUMAN 

 MAMMARY GLAND. 



A, a basophile 

 cell; B, an eosino- 

 phile cell. Hema- 

 tein and eosin. X 

 750. 



