THE ALIMENTARY CANAL 



355 



as long as the duct or foveola, a fact which sharply differentiates the 

 fundic from the pyloric glands of the stomach. The lumen of the se- 

 creting portion is so narrow as to be 

 scarcely perceptible except by the use 

 of special stains (precipitation tech- 

 nics) or high magnification. 



The fundus of the gland is lined 

 by two distinct cell types, the chief 

 and' the parietal cells. The chief cells 

 are relatively more abundant at the 

 deeper portion of the fundus, where 

 they form a complete lining for the 

 tubule. In this portion the parietal 

 cells are crowded away from the lu- 

 men and consequently produce a 

 bulging of the basement membrane. 

 Toward the neck of the tubule the 

 parietal cells are more abundant and 

 draw progressively nearer and nearer 

 the lumen until, in the neck of the 

 gland, they possess a considerable free 

 surface which encroaches upon the 

 glandular lumen. 



The Chief Cells (Central Peptic, 

 or Adelomorphous Cells). The chief 

 cells possess a cuboidal or pyramidal 

 shape and a granular cytoplasm. The 

 spheroidal nucleus is situated in the 

 proximal or attached end, while the 

 distal end of the cell is its most gran- 

 ular portion. The breadth of the 

 granular zone is dependent upon the 

 state of secretory activity, the coarse 

 zymogen granules accumulating dur- 

 ing periods of rest and disappearing 

 by secretion during activity. Thus 

 the granular distal zone increases in 

 breadth during rest and decreases during activity. The whole cell also, be- 

 comes shrunken after prolonged secretion, but during rest it becomes so 

 swollen that with its neighbors it nearly occludes the lumen of the tubule. 



FIG. 331. LONGITUDINAL SECTION 

 OF THE FUNDUS GLANDS OF MAN. 

 b, parietal cells; g, fundus of the 

 gland; h, chief cells; k, body, and /, 

 neck of the gland; m, nmscularis 

 mucosse; Mg, gastric crypts. X 85. 

 (After Kolliker.) 



