MYCETOMA, OR MADURA-FOOT. 215 



Vincent was nnable to communicate the disease to animals 

 by inoculation. 



Microscopic study of the diseased tissues in cases of 

 mycetoma is not without interest. The healthy tissue 

 is said to be sharply separated from the diseased masses. 

 The latter appear as large degenerated tubercles, except 

 that they are extremely vascular. The mycelial or 

 filamentous fungous mass occupies the centre of the 

 degeneration, where its long filaments can be beautifully 

 demonstrated by the use of appropriate stains, Gram's 

 method being excellent for the purpose. The tissue sur- 

 rounding the disease-nodes is infiltrated with small round 

 cells. The youngest nodules are seen to consist of granu- 

 lation-tissue, which in its organization is checked by the 

 coagulation-necrosis which is sure to overtake it. Giant- 

 cells are few. 



Not infrequently small hemorrhages occur from the 

 ulcers and sinuses of the diseased tissues ; the hemor- 

 rhages can be explained from the abundance of small 

 blood-vessels in the diseased tissue. 



Although the disease has been described as occurring 

 in Scinde, it is not limited to that province, having been 

 met with in Madura, Hissar, Bicanir, Dehli, Bombay, 

 Baratpur, Morocco, Algeria, one case by Bastini and 

 Campana in Italy, and one by Kempner in America. 



