CHAPTER XXIV 

 DIABETES 



By R. T. Woodyatt 



Introduction. — As with gout and the problems of purine metabo- 

 hsm, so with diabetes a vast amount of study has been expended be- 

 cause of the integral connection of this disease with broader problems 

 of physiology, and in particular with the metabolism of the carbo- 

 hydrates and the fats, the nature of internal secretions, and the func- 

 tion of the kidneys. It is impossible in this place to review the entire 

 literature and history of the subject, a key to which will be found in 

 the works of the writers cited below. ^ This chapter will be devoted 

 only to an outline of the chief established facts, with an indication of 

 the main hnes along which the thought of leading students has been 

 directed. It will involve a brief discussion of the problems of carbo- 

 hydrate physiology, but only in so far as they are contingent upon the 

 main topic — while for a discussion of that anomaly of the metabolism 



1 Older Ldterature: 

 Bouchardat — De la glycosurie ou diabete sucrc, Paris, 1875. 

 Kiilz — -Beitrage zur Path, und Ther. der Diabetes Melitus, Marburg, 1874- 



5. 

 Bernard — Legons sur le Diabete et la Glycogenese Animale, Paris, 1877; 



Vorlesungen iiber Diabetes, Berlin, 1878. 

 Cantani — Diabetes Melitus (German translation by Kahn), Berlin, 1880. 

 Frerichs — Ueber den Diabetes, Berlin, 18S-4. 

 Larger Works: 



Naunyn — Der Diabetes Melitus, Berlin, 1906. Diabetes Melitus; in Noth- 



nagel's Handbuch (2nd), Vienna, 1906. 

 Lepine — Le diabete sucre, Paris, 1909. 

 von Noorden — (a) Die Zuckerkrankheit (6th), Berlin, 1912. (b) New 



Aspects of Diabetes, New York, 1913. 

 Pavy — Carbohydrate Metabolism and Diabetes, London, 1906. 

 McLeod — Diabetes (Longmans, Green), 1918. 



Cammidge — Glycosuria and Allied Conditions. (Longmans, Green), 1913. 

 Allen — Glycosuria and Diabetes, Boston, 1913. 

 Foster — Diabetes Melitus, Philadelphia, 1915. 

 Joslin — Treatment of Diabetes Melitus, New York, 3rd. Ed., 1919. 

 Monographs, etc.: 



Magnus-Levj^ — Diabetes Melitus; in Kraus and Brugsch, Spezielle Path. u. 



Ther. innerer Krankheiten, Berlin, 1913. 

 Gigon — Neuere Diabetes Forschungen, Ergebnisse der inneren Medizin, 



1912, IX, p. 206. 

 von Mering — Behandlung der Diabetes melitus; in Penzoldt and Stinzing's 



Handbuch der Spezielle Therapie (2nd), 1912. 

 Lusk — Elements of the Science of Nutrition (3rd), New York, 1917. 

 Benedict and Joslin — Metabolism in Diabetes Melitus, Carnegie Institu- 

 tion, Washington, 1910. 

 Benedict and Joslin — A Study of Metabolism in Severe Diabetes, ibid., 1912. 

 Allen, Stillman and Fitz — Total Dietary Regulation in the Treatment of 

 Diabetes. Monograph of the Rockefeller Institute for Medical Research, 

 New York, 1919. 



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