434 RETROGRESSIVE CHAyCES 



cent, in advanced stages, but absent in bronchial catarrh ; in pneu- 

 monia .05 per cent, was found, in putrid bronchitis 0.25 per cent. 

 (Pozzilli). When glvcouen solution (1 per cent.) is injected into the 

 peritoneal cavity, the endothelial cells and invading leucocytes become 

 loaded with glycogen granules. 



Glycogenic Infiltration in Diabetes. — It is in diabetes, however^ 

 that tiie iiKist marked acnimulatious of glycogen are found, the gran- 

 ules frequently fusing in the cells into droplets larger than the nu- 

 cleus ; when dissolved out in ordinary- microscopic preparations, the 

 clear round space left is exactly like the space left by a fat-droplet, 

 except that the margins show a tendency to take the basic stain for 

 some unknown reason. In even the most extreme cases, however, 

 the nucleus is well preserved, although it, too, may contain large 

 masses of glycogen, in which case there is no glycogen in the cyto- 

 plasm.*^ Glycogen is found particularly in the epithelium of Henle's 

 tubules,*'^ in heart muscle, and in the leucocytes, whereas it is greatly 

 diminished in the normal storehouses of glycogen, the liver and mus- 

 cles. Fiitterer describes masses of glycogen in the cerebral capil- 

 laries, resembling an embolic process; it is also present in the tissues 

 of the eye.**' Sandmeyer analyzed the organs for glycogen in a case 

 of diabetes, finding the following amounts in percentage of organ 

 weight: liver, 0.613; kidneys, 0.1158; lungs, 0.0442; spleen, 0.07. 

 Experimental diabetes (pancreas extirpation) produces a marked glj'- 

 eogenic infiltration. 



47 Askanazy and Hiibschmann, Cent. f. Path., 1907 (18), 641. 



48 See Fahf, Cent. f. Path., 1911 (22), 94.5. 



49 Shimagav/ora, Klin. Monatsbl. Augenheilk., 1911 (12), 682. 



