,,,;.; U/NVA'V O/' 77//; /'A'OCESS OF CALCIFIC.iTIOy 439 



T 1 .,lk.,lino and an increase in the alkalinity of the 

 oorresponchngly ^^^'^.^"\'' 'Vt'^ecidedlv less soluble. In the stomach 

 fluids makes the calcumi ^f ^^J^^^^'^ ^^^ter-landular tissue about 

 the ealeium deposits ^^ ^J^i::^:':..^ corresponding 

 the upper portion of the ?U>^^*^ .^.^^osed to secrete the acid. Pre- 

 to the parietal cells which '^V^ "^^^j ^''' J,,,,,t of calcium in the 



blood IS too slignt to ue uiiu skeleton, precipita- 



attemrted to include 'l;^"^!"'*',!^^'^.^^ ^cX , h oVi.in of the 

 in old age in the metastatic =«1"«°'^*'°°'' *'";"" bably dependent 

 salts to the senile f -'T'*-" .^^ ^''™ :;„tltfon oft^^^^^ tis- 



:^:JZ:^ rtrs:r iSe\ot:"Tchan,e .... .een. to he 



rCo'lra^tpoSnffaeto't^tt: solTtion of ealeinn. salt. ,n 



111 rt the Uo d%s tcreS hviniectin, or feedin. calcium 

 : t deposi«ons ot calcium salts may take place m injured tissues, 

 or even in normal tissues, as in Tanaka's experiments. • 



CHEMISTRY OF THE PROCESS OF CALCIFICATION 

 Tn analv^iuK the etiological factors in the production of pathologi- 



bo at an phosphate themselves, or as ealcium-ion-protem com- 

 ^o nds or perhaps both. This suspension or solution is an unstable 

 eondt;., poss ble only because of the extremely small proportion o 

 calctm"n ^e blood (about 1 :in,O0O), and. therefore, capable of 

 be n"mcrtl rown bv increased alkalinity of the blood, changes m the 

 prtSiiis or CO, content, or changes in the quantity or composition 



r u 1 • „„+ " -NT T5 «5p>innAt has described a case with 



,eS^/^;ST„„°l,':;,'fcZ no. ^L »^^ „™..K- allele, in 



physiol. Chem'., 1913 (S5). 324. iqnTn) 1 



"^:STzSi^^r\^^r^rnif:^': i« a.Vo Kata., Be... pa.„. 

 Anat., 1914 (57), 516. 



