MEI.AyorlC TUMOItH ■*'' 



„.. .kin Ilclman found »onic evidence of toxicity when lar^e doses of 

 .ehn in d" 1 e n sodium earbonate are injected njto an.mals. but 



an,ns. Iron .s £ •'^ "t .Y 1™ ,an,ixture of blood-pipnent 



Crtr^nrol'c^a'troSanin^ba^sJroducedbythe^um^^^ 



comatou lner.300grams^ states that the melanin may con- 



'h,' fte"7 3 per c/nt by vve ght of the fresh substance of some melano- 

 :ar:omIs Tccorlfto Utbarsch and to Helman, melauotrc tumors 



'•^t';ritefZ:;Neuber. found that a "elastic -coma;^^^ 



,a^eWense.»tlon^^ 



trvDtophane was tea to a pdniiu. v. ^ \^^A\- tn 



melamiria He therefore concludes that tlie power of the bod> to 

 r.tr the Dvrrole rin- is reduced, and instead it undergoes reduc- 

 tTLZ^^n, ^ion with sulphuric ^id to W ^^^al 

 s„lnhate of methvlpvrrolidlne-hydroxy-earbonic acid (CH,-b,li.lN..U4 ) . 

 XbdJhalto-' also found a relation to tryptophane, for m the urme 

 ^f atianuric was present a substance rich in tr,-p.opl.ane ; and 



13 \roh internat. Plmnnakodynam., 1003 (1-). 



14 Jour. Med. Res., V.m (16), 117. 

 isVirchow's Arch.. 1000 (108). 62. 

 16-Biochem. Zeit., 1010 (28). ISl 

 iTZeit. physiol. Chem., 1912 (/8), 159. 



