510 Till-: Clll^MlSTh') OF Tl MORS 



liypoxanthine, 25 per cent. The relatively large proportion of pre- 

 formed hypoxantliine corresponds with the abundance of this purine 

 free in unstriated muscle. Fibromyomas are able to deamidize their 

 guanine and adenine to xanthine and hypoxantliine, and contain 

 guanase but not adenase. Extracts from uterine fibromyomas show 

 practically^ the same composition as extracts of normal uterus. ^''^ 



A uterine fibroid analyzed by Becbe ^* contained 14.56 per cent, of 

 nitrogen, 0.981 per cent, of sulphur, 0.139 per cent, of phosphorus, 

 0.013 per cent, of iron, 0.12 per cent, of calcium oxide, 0.44 per cent, 

 of potassium, and 1.115 per cent, of sodium. The proportions of ni- 

 trogen and sulphur are high as compared with most tumors; the phos- 

 pliorus, iron, and potassium are low, corresponding to the small 

 amount of nucleoprotein and the slow rate of growth. If degenera- 

 tion is marked, the amount of calcium is greatly increased. Kraw- 

 kow ^" found a trace of chondroitin-sulphuric acid in a uterine fibroid. 

 Lubarsch found glycogen occasionally in richly cellular uterine leio- 

 myomas, and in the vicinity of degenerating areas; however, 76 out of 

 85 showed no glycogen. Pfannenstiel -° analyzed the alkaline fluid 

 of a cystic fibromyoma, which coagulated spontaneously ; it contained 

 sugar, but no mucin or pseudomucin. The cysts were dilated lymph- 

 spaces, and the fluid corresponded to lymph in composition. A simi- 

 lar result was obtained by Oerum,-^ who found in the fluid serum- 

 albumin, serum-globulin, and 0.358 per cent, of fibrin; the total pro- 

 teins constituted 6.3056 per cent. Sollmann — found in the "colloid" 

 of a cystic degenerated fibromyoma both pseudomucin and paramucin 

 (see "Ovarian Cysts"), which differed somewhat from the same sub- 

 stances found in ovarian tumors. From a myxoma of the back Os- 

 wald --'■' obtained a mucin with the following elementally composition : 

 C, 50.82 ; H, 7.27 ; N, 12.24 ; S, 1.19 ; P, 0.25 per cent. This differs 

 from other mammalian mucins in the presence of phosphorus, but 

 Oswald does not consider this a contamination. It also contained 12 

 per cent, of carbohydrate, apparently glucosamine. 



The common occurrence of marked cardiac weakness in patients 

 with uterine fibroids has led to the suggestion that in the fibroids some 

 toxic product is formed which acts on the heart, or that both the fibroid 

 and the heart defect might result from a common cause. The experi- 

 mental evidence concerning the relationship is not convincing, and 

 there is much ground for the belief that the heart suffers from the 

 anemia common in these eases.^^ There is said to be a hemolytic poi- 



i7aWini\vaif<T. Arcli. f. ClvnJik.. 191.3 (100), i530. 

 isAmcr. Jour. Plivsiol., 1!)04 (12), 107. 

 i!>Arch. cxp. Path! u. Pharm., 1898 (40), 195. 

 20 Areh. f. Ovn., 1890 (38), 4(58. 

 2iMalv's Jahrosbcr., 1884 (14), 462. 



22 Amcr. Oynccol., 1903 (2), 232. 



22a Zcit. i)li.VKi(.!. ("hcni., 1914 (92). Ml. 



23 Sw Jasciiko, Mitt. Crenz. Mod. u, Cliir., 1912 (lo). 249; IMcCliini, Suifr., 

 Gvn., Olist., 1914 (18), 180. 



