j:\<)i'iiTii\i.\iic (:<)iTi:i{ OOf) 



ill ('.\()|)litlialiiii(' ^'•oitcr, Mai'ine contends that it has hccii pn-ccdcd 

 by a hyi)('i'j)histi(' stajiO."'' 



Based on tlie tlieory that the iioi-mal function of tlie thyroid is the 

 detoxieation of metabolic products, is the sernni treatment advocated 

 first by Ballet and Kni-i(iu('/., and later by Lanz, and Burghart and 

 ]-}lnnienthal;'' On tlic ])rinei})le that after thyroidectomy tiie l)lood 

 should contain an acennudation of those substances, which the thyroid 

 normally neutralizes, they injected the serum of thyroidectomized 

 goats into patients with exophthalmic goiter, in the hope that these ac- 

 cumulated substances might in turn neutralize any excessive thyroid 

 secretion. Favorable results were obtained, and it was subsequently 

 found that the milk of thyroidectomized goats possesses the same qual- 

 ities, and may be administered by mouth ; this has led to ([uite exten- 

 sive clinical use of this method of treatment, which has failed to show 

 any regidar beneficial effects in the hands of most careful observers."-'' 

 Of similar significance are the favorable effects obtained by Beebe''* 

 and Rogers '" with a serum made by immunization of animals with the 

 mu'leoproteins of the thyroid, which have not been corroborated by 

 others. 



Oswald *'* found that the thyroid in exophthalmic goiter contains 

 generally a smaller proportion of iodin than normal glands, but with 

 the total amount approximately normal. However, the findings are 

 very inconstant, corresponding with the fact that in some cases of 

 exophthalmic goiter the amount of colloid is abundant (in which case 

 the amount of iodin may be large), while usually the amount of colloid 

 is small, and its highly vacuolated condition in hardened sections 

 suggests that it is of unusually fluid consistency. A. Kocher *^ found 

 that either the amount of iodin is small, which is usual, or else very 

 high, but it is seldom the same as in normal thyroids ; the more dense 

 the colloid in the follicles the higher iodin content he observed; the 

 phosphorus content is both relatively and absolutely increased. ^la- 

 rine has found that in exophthalmic goiter as well as in other conditions 

 the amount of iodin is in direct proportion to the colloid and inverse 

 to the hyperplasia. E. V. Smith ^^'' obtained in simple hyperplastic 

 glands an average of 0.54 mg. of iodin per gram dry weight, as com- 

 pared with 1.52 mg. in hyperi)lastic glands showing retrogressive 

 changes with more densely staining colloid. P^onio found that, as with 

 normal thyroids, the physiological effect of exophthalmic goiter glands 



70 See also Wilson. Amer. Jour. Med. Sci., lilOS (136). .S.jI. 



TTDeut. med. Woch., 1899 (25), 627. Also Mobiua, Miiiicli. mo.l. Woi-li.. I'.tOl 

 (48), 185.3; v. Levden, :\Ied. Klinik. 1904 (1), 1; Kuloiihor'r. I'.crl. kiiii. Woch.. 

 1905 (42), 3. 



"a See Sonne, Zeit. klin. Mod.. 1914 (?0), 229. 



78 Jour. Amer. ^Med. Assoc, 1906 (4()), 484; 1900 (47). 6.)5. 



-^ Ihid., 1900 (40), 487; 1006 (47), 001. 



soVirchow's Areli., 1902 (109), 475. 



siVirchow's Ardi., 1912 (208). 80. 



81a Jour. Amer. Med. Assoc., 1914 i02). 113. 



