634 URICACID METABOLISM AXD GOUT 



posits by intravenous injection into ral)l)its of at least 0.08 gm. per 

 kilo, but subcutaneous injections were ineffective; injury to the renal 

 epithelium by whatever cause interferes with this deposition of urates. 

 These experimental infarctions are undoubtedly related to the human 

 form, and indicate that the latter dej)end upon the presence of an ex- 

 cessive amount of uric acid in the infants' urine, in which a ratio of 

 uric acid to urea of 7.9 to 74.9, as against the adult ratio of about 2 

 to 85, was found by Sjoquist. According to Niemann,^^ in .the first 

 few days of life the infant excretes from 80 to 100 mg. of uric acid 

 daily, while after the fifth day the amount falls to 30 to 40 mg. daily. 

 Similar figures were obtained by Schloss and Crawford, ^^ who also 

 found a corresponding increase in the phosphoric acid, showing that 

 the uric acid must originate from nucleoproteins. 



Adult kidneys may also .show uric acid deposits in the tubules of 

 the papilla?, independent of gout. They occur as a result of cell de- 

 composition, according to IM. B. Schmidt,^** who found them especially 

 in pneumonia, leukemia and sarcoma, but not in carcinoma. 



37 Jahrb. f. Kinderheilk., 1910 f71), 286. 

 38Amer. Jour. Dis. Cliildren. 1911 (1), 203. 

 39 Verb. dent. Path. Ges., 1913 (16), 329. 



