CHAPTER XXI I 



DIABETES 

 By R. T. Woody ATT. 



Introduction. — As witli gout and the problems of purine metabo- 

 lism, so with diabetes a vast amount of study has been expended be- 

 cause of the integral couneetion of this disease with the broader prob- 

 lems of carbohydrate phj^siology, the metabolism of the fats and the 

 nature of internal secretions. It is impossible in this place to review 

 the entire literature and history of the subject, a key to w'hich will be 

 found in the works of the writers cited below. ^ This chapter will be 

 devoted only to an outline of the chief established facts, with an 

 indication of the main lines along which the thought of leading 

 students has been directed. It will involve a brief discussion of the 

 problems of carbohydrate pln'siology, but only in so far as they are 

 contingent upon the main topic — while for a discussion of the anom- 



1 Older Literature: 



Bouchardat — De la orlycosurie ou diabfete sucre, Paris, 1875. 

 Kiilz — Beitriige zur Path, und Ther. der Diabetes Melitus, Marburg, 1874-5. 

 Bernard — LeQons sur le Dial)i'ti' et la (Tlycogenese Aniniale. I'aris, 1877: 

 Vorlesungen iiber Diabetes, Berlin, 1878. 

 Cantani — Diabetes Melitus (German translation by Kalin), Berlin, 1880. 

 Frerichs — Ueber den Diabetes, Berlin, 1884. 



Larger Works: 



Naunyn — Der Diabetes ]\Ielitus, Berlin, 1906. Diabetes Melitus; in Xoth- 



nagel's Ilandbuch (2nd), Vienna, 1906. 

 Lepine — Le diabete sucre, Paris, 1909. 

 von Noorden — (a) Die Zuckerkrankheit (6th), Berlin, 1912. (b) Xew 



Aspects of Diabetes, New York, 1913. 

 Pavy — Car))ohydrate Metabolism and Diabetes, London, 1906. 

 McLeod — Diabetes (Longmans, Green), 1913. 



C'amniidge — Glycosuria and Allied Conditions. (Longmans, Green), 1913. 

 Allen — (jllvcosuria and Dial)etes, Boston, 1913. 

 Foster— Diabetes .Melitus, Philadelphia, 1915. 

 Joslin — Treatment of Diabetes Melitus, New York, 1916. 



Monographs, etc. : 



Magnus-Levy — Diabetes Melitus; in Kraus and Brugsch, Spezielle Path. u. 

 Ther. innerer Krankheiten, Berlin, 1913. 



Gigon — Neuere Diabetes Forschungen. Ergebnisse der inneren Medizin, 

 1912, IX, p. 206. 



von Mering — Behandlung der Diabetes melitus; in Penzoldt and Stinzing's 

 Handbuoh der Spezielle 'I'herapie 1 2nd), 1912. 



Lusk — Elements of the Science of Nutrition (3rd), New York, 1917. 



Benedict and Joslin — Metabolism in Diabetes Melitus, Carnegie Institu- 

 tion, Washington, 1910. 



Benedict and Joslin — A Study of ^letabolisni in Severe Diabetes, ibid., 1912. 



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