THE NATURAL DISEASE 307 



In horseS the lesions are of two types, to which the names "glanders " 

 proper and "farcy" have been given, though both may exist together. 

 In glanders proper, the septum nasi and adjacent parts are chiefly atfected, 

 there occurring in the mucous membrane nodules which are at first firm 

 and of somewhat translucent grey appearance. The growth of these is 

 attended usually by inflammatory swelling and profuse catarrhal dis- 

 charge. Afterwards the nodules soften in the centre, break down, and 

 give rise to irregular liberations. Similar lesions, though in less degree, 

 may be found in the respiratory passages. Associated with these lesions 

 there is usually implication of the lymphathic glands in the neck, media- 

 stinum, etc. ; and there may be in the lungs, spleen, liver, etc., nodules 

 of the size of a pea or larger, of greyish or yellow tint, firm or somewhat 

 softened in the centre, and often surrounded by a congested zone. The 

 term "farcy" is applied to the affection of the superficial lymphatic 

 vessels and glands, which is specially seen where infection takes place 

 through an abrasion of the skin, such as is often produced by the rubbing 

 of the harness. The lymphatic vessels become irregularly thickened, so 

 as to appear like knotted cords, and the associated lymphatic glands 

 become enlarged and firm, though suppurative softening usually follows, 

 and there may be ulceration. These thickenings are often spoken of as 

 " farcy buds " and " farcy pipes." In farcy, also, secondary nodules may 

 occur in internal organs and the nasal mucous membrane. The disease 

 is often present in a " latent form," and its presence can only be detected 

 by the mallein test (vide infra). In the ass the disease runs a more 

 acute course than in the horse. 



In man the disease is met with in two forms, an acute and a 

 chronic though intermediate forms also occur, and chronic cases 

 may take on the characters of the acute disease. The site of 

 inoculation is usually on the hand or arm, by means of some 

 scratch or abrasion, or possibly by infection along a hair follicle, 

 sometimes on the face, and occasionally on the mucous membrane 

 of the mouth, nose, or eye. In the acute form there appears at 

 the site of inoculation inflammatory swelling, attended usually with 

 spreading redness, and the lymphatics in relation to the part also 

 become inflamed, the appearances being those of a " poisoned 

 wound." These local changes are soon followed by marked 

 constitutional disturbance, and by a local or widespread eruption 

 on the surface of the body, at first papular and afterwards 

 pustular, and later there may form in the subcutaneous tissue 

 and muscles larger masses which soften and suppurate, the pus 

 being often mixed with blood ; suppuration may occur also in the 

 joints. In some cases the nasal mucous membrane may be 

 secondarily infected, and thence inflammatory swelling may 

 spread to the tissues of the face. The patient usually dies in 

 two or three weeks, sometimes sooner, with the symptoms of 

 rapid pyaemia. In addition to the lesions mentioned, there may 

 be foci, usually suppurative, in the lungs (attended often with 

 pneumonic consolidation), in the spleen, liver, bone-marrow, 



