TRYPANOSOMA OF SLEEPING SICKNESS 623 



7'/-t/j>anosoma f/ambiense. Before going further we must refer 

 to the observation of a trypanosome in the blood of persons not 

 i-vidi'iitly suffering from sleeping sickness. The first case of 

 this was recorded by Dutton in 1901, the patient being a 

 European then living at Bathurst on the Gambia. The progress 

 of the disease was here very slow, and was characterised by 

 general wasting and weakness, irregular rises of temperature, 

 local oedemas, congested areas of the skin, enlargement of spleen, 



> 



FIG. 172. Trvpanosoma garnbiense from blood of guinea-pig, x 1000. 

 See also Plate VI., Fig. 25. 



and increased frequency of pulse and respiration ; death occurred 

 a year after the case came under observation after an access of 

 fever, and a striking fact was the absence of any gross causal 

 K'sion. During the time the patient was under observation 

 trypanosomes were repeatedly demonstrated in the peripheral 

 blood, and they also developed in the bodies of monkeys and 

 white rats inoculated with the blood. Pursuing further in- 

 quiries, Dutton and Todd demonstrated similar parasites] tin 

 other Europeans and in several natives in the Gambia region, 



