CONTENTS Xl 



CHAPTER IX 



THE ANTHRAX PROTEIN 



Literature, investigations; the anthrax cellular substance, like 

 other proteins, contains a poison; sensitization with anthrax protein 189 



CHAPTER X 



THE CELLULAR SUBSTANCE OF THE PNEUMOCOCCUS 

 Difference in virulence in strains; properties and effects on animals 

 of the cellular substance; the action of the poisonous portion; auto- 

 lysis of the pneumococcus; sensitization with pneumococcus protein 205 



CHAPTER XI 



PROTEIN SENSITIZATION 



Introduction; definition; the sensitizer; all true proteins sensitize; 

 volatile sensitizers; the sensitizing group in the protein molecule; 

 the effects on different animals; period of incubation; the anaphyl- 

 actic state; the reinjection; symptoms; the mechanism of anaphyl- 

 axis; passive anaphylaxis; anti-anaphylaxis; the Arthus phenomenon; 

 anaphylaxis and toxic sera; the toxogens; anaphylaxis in vitro; the 

 poison; j8-iminazolylethylamin; the kyrins; anaphylatoxin ; physio- 

 logical action of the protein poison; general physiological action of 

 proteins; sensitization is cellular; theories; theory of Friedberger; 

 1 theory of Vaughan and Wheeler; theory of Nolf 214 



CHAPTER XII 



PARENTERAL DIGESTION 



The disposition of peptones; the fate of proteins introduced 

 directly into the circulation; the' poisonous action of proteins; egg- 

 white injected into the stomach of a rabbit may be in part absorbed 

 unchanged; egg-white injected into the rectum of a rabbit may be, 

 in part at least, absorbed unchanged; egg-white injected into the 

 peritoneal cavity of a rabbit may be absorbed unchanged; egg- 

 white injected intravenously in a rabbit quickly disappears from the 

 circulating blood; egg-white injected intravenously in a rabbit may 

 be detected in the peritoneal cavity, in the bile, and in certain 

 organs after it has disappeared from the circulating blood; the 'njec- 

 tion of a large amount of egg-white intravenously in a rabbit may 

 prove fatal; the blood is a digestive fluid; proteolytic digestion in 

 the blood is regulated by the accumulation of digestive products . 342 



