204 



PROTEIN POISONS 



bacterial proteins is an unwarranted assumption, and that 

 it is not poisonous in any dose we have shown not to be 

 true. When the anthrax protein is obtained in solution 

 without alteration of its constitution, and when this solu- 

 tion is properly administered we dare say that it will be 

 found to sensitize animals as well as any other protein. 

 As we have had occasion to point out more than once, 

 it is necessary to have a protein in solution in order to 

 develop exquisite sensitization, and it must be in solution on 

 reinjection in order to induce the most striking form of 

 anaphylactic shock. Permeation of the body cells seems to 

 be essential to the most complete sensitization, also to its 

 demonstration on reinjection. 



Roos 1 has shown that salvarsan is an effecient germicide 

 for the anthrax bacillus, both in vitro and in vivo, and 

 Becker 2 and Bettman 3 have successfully treated anthrax 

 in man with this preparation. 



1 Zeitsch. f. Immunitatsforschung, 1912. xv, 487. 

 z Deutsch. med. Woch., 1911. 

 3 Ibid., 1912. 



