224 PROTEIN POISONS 



animals sensitized to cows' serum were not affected on the 

 subsequent injection of cows' milk, and vice versa. Wells 1 

 obtained results that were not constant. Uhlenhuth and 

 Handel 2 and Thomsen 3 did sensitize to serum with milk and 

 vice versa; the latter used woman's milk and human serum. 

 Bauer 4 by fixation of the complement method seems to have 

 shown that the albumin and globulin of milk are closely 

 related to the same constituents of the blood, while the 

 casein of the milk is a protein unlike any in the blood. 

 This is probably correct and explains the inconstancy in 

 the experiments. 



The differences between the proteins of the blood serum 

 and those of the erythrocytes have been demonstrated 

 by the anaphylactic reaction. This has been shown uni- 

 formly by the experiments of H. Pfeiffer, 5 Pfeiffer and 

 Mita, 6 Thomsen, 7 Doerr and Moldovan, 8 and Uhlenhuth 

 and Handel. 9 These investigators have found it impossible 

 to sensitize guinea-pigs against blood serum with erythro- 

 cytes and vice versa. In demonstrating this fact it is necessary 

 to fully separate the corpuscles and serum. The corpuscles 

 should be well washed in order to accomplish this, and 

 provision must be made against solution of the corpuscles 

 in the serum. The corpuscles of each species contain 

 specific proteins and therefore those of one species do not 

 sensitize to those of another. 



According to Dunbar, 10 the sexual cells are as specific as 

 blood sera. The proteins of organ extracts are specific as 

 between different species of animals, with some exceptions 

 to be noted later, but as between different organs from the 

 same species, and between the blood serum and organ 



Loc. cit. 



Zeitsch. f. Immunitatsforschung, iv, 761. 3 Ibid., iii, 539. 



Munch, med. Woch., 1908, No. 16; Zeitschr. f. exper. Path. u. Ther., 

 1909, vii. 



Zeitsch. f. Immunitatsforschung, 1910, viii. 



Ibid., vi; ibid., v. ' Ibid., i; ibid., iii. 



>> Zeitsch. f. Bakt. Ref., v. 

 Zeitsch. f. Immunitatsforschung, iv, 761. 

 10 Ibid., 740; vii, 454. 



