258 PROTEIN POISONS 



The following additional facts concerning passive ana- 

 phylaxis are of importance and will be referred to again 

 when we come to discuss the theories of anaphylaxis: 



1. Otto 1 has shown that blood-serum taken from an 

 animal in the pre-anaphylactic stage (eight days after the 

 first injection of horse serum) sensitizes recipients. 



2. Gay and Southard and others have shown that the 

 blood-serum taken from animals in the so-called anti- 

 anaphylactic state sensitizes the recipients. 



3. Otto has shown that a third species of animal may 

 be used to demonstrate anaphylaxis; thus, a guinea-pig 

 which has been treated with rabbit-antihorse serum mani- 

 fests anaphylactic symptoms when subsequently treated 

 with horse serum. We 2 have shown that under proper 

 conditions the anaphylactic poison may be generated 

 in vitro. 



Besredka 3 in discussing passive anaphylaxis states that 

 results are inconstant. In our opinion this is due to the 

 difficulty in securing the proper proportion between the 

 antigen and the anaphylactic serum introduced into the 

 recipient. 



Anti-anaphylaxis. We wish to join Friedemann 4 in a 

 protest against the use of this term. However, as Friede- 

 mann states, it is so deeply embedded in the literature of 

 anaphylaxis that it cannot be omitted. German and 

 American authors are not the only ones who object to the 

 term anti-anaphylaxis, and the explanation of it given by 

 Besredka and Steinhardt. Levaditi 5 has produced potent 

 arguments against the views of his confreres. The work 

 done by Besredka and Steinhardt is of the highest value, 

 but we differ from them in the explanation of their results. 

 As Levaditi states, we owe the discovery of this condition 

 to Otto and to Rosenau and Anderson, but the name and 



1 Munch, med. Woch., 1907, No. 39. 



2 Zeitschr. f. Immunitatsforschung, xi, 673. 



3 Kraus and Levaditi, Handbuch d. Technik u. Methodik d. Immuni- 

 tatsforschung, Erganzungsband i, 240. 



4 Jahresbericht u. d. Ergeb. d. Immunitatsforschung, 1910, vi, 54. 

 * Ibid., iii, 37. 



