PROTEIN SENSITIZATION OR ANAPHYLAXIS 271 



Friedberger's excellent work on the extraction of the 

 anaphylactic poison from bacteria shows the necessity of 

 attending to the quantitative proportions between the 

 bacteria, amboceptor, and complement, also that the 

 poison may be destroyed by prolonged digestion. The 

 amount of cellular substance necessary to supply a fatal 

 dose of the poison is smaller than the lethal dose of the 

 living, unbroken cells. This confirms our work, for we 

 demonstrated some years ago that the protein poison is 

 only a part of the larger molecule which is a part of the 

 cell. The greater part of the bacterial cell is, after the 

 removal of the poisonous portion, wholly without toxic 

 action. Neufeld and Dold have shown that there is no 

 relation between the amount of poison in a given bacillus 

 and its pathogenic action, and Friedberger and Goldschmidt 1 

 have obtained the anaphylactic poison from the prodigiosus 

 and other non-pathogenic bacteria. All of this is confirma- 

 tory of work we did many years ago. In 1902 we published 

 the following findings: 



THE EFFECTS OF INTBAPEKITONEAL INJECTIONS OF THE AIR-DRIED CELLS 

 OF THE BACILLUS PRODIGIOSUS IN GUINEA-PIGS 



No. Weight in gm. ' Dose in mg. Result. 



1 260 50 + 



2 305 50 + 



3 287 20 + 



4 ...... 272 10 + 



5 260 5 + 



6 270 3 + 



7 252 2 



8 252 1 



THE EFFECTS OF INTRAPERITONEAL INJECTIONS OF THE AIR-DRIED 

 CELLS OF THE BACILLUS VIOLACEUS IN GUINEA-PIGS 



No. Weight in gm. Dose in mg. Result. 



1 220 30 + 



2 230 20 + 



3 255 15 + 



4 265 10 + 



5 210 5 



1 Zeitsch. f. Immunitiitsforschung, vi, 299. 



