372 PROTEIN POISONS 



ether anesthesia, a small normal dog (A), and to transfuse 

 this animal by Crile's method, with the blood of a larger 

 sensitized dog (B), until the blood pressure reached approxi- 

 mately its original level. After sufficient blood has been 

 obtained from B to raise the pressure of A, the sensitized 

 dog is then bled to exsanguination and transfused from a 

 third normal dog (C) until its pressure reaches its previous 

 normal level. At the proper moment, the normal dog 

 containing the blood of the sensitized dog and the latter 

 containing the blood of the normal dog, each receives 

 intravenously the toxic dose of horse serum. In the former, 

 a fall in pressure does not occur, and in the latter it does, 

 thus proving that the phenomenon of anaphylaxis is due 

 to a reaction in the fixed cells, and not either primarily or 

 secondarily in the blood." That the blood does under 

 certain conditions at least contain the specific ferment is 

 shown by the production of passive anaphylaxis. 



