376 



PROTEIN POISONS 



fever, and yet without infection. In the infectious diseases 

 the invading, multiplying cell supplies the foreign protein; 

 in this experiment the supply of foreign protein has been 

 kept up by the frequency of the injections. The amount of 

 urine is variable, but averages less than normal as it does 

 in the continued fever of man. The elimination of nitrogen 

 is increased. During the twenty-four hours immediately 

 following the first dose the temperature kept below the 

 normal average, and each time the dose was doubled a 

 marked rise followed in twenty-four hours. There is the 



+FIR3T INJECTION OF SERIES 



i-.-ld r.-l i G-12 6-13 6-14 6-15 6-1G 6-17 C-1S 



C-20 C-21 6-22 



+ LA3T INJECTION OF SERIES 



FIG. 12. The production of continued fever in a rabbit by repeated 

 subcutaneous injections of egg-white. 



gradual rise in the morning temperature, so frequently seen 

 in typhoid fever and the fact that for the most part the 

 highest temperature for the day falls in the afternoon is 

 also interesting. When the injections were discontinued 

 the temperature gradually fell and remained somewhat 

 below the normal, as is often observed in convalesence 

 from typhoid fever. 



We wished to ascertain the source of the albumin in the 

 urine; did it consist wholly of egg albumen or serum albumin, 

 or did it contain both? In order to determine this we 

 injected 2 c.c. of the filtered urine on June 18, intra-abdomi- 



