378 



PROTEIN POISONS 



about 10 per ceixt. of the poison in the purest form in which 

 we have been able to obtain it. This crude soluble poison 

 was administered every two hours from 7 A.M. to 9 P.M 

 from May 3 to May 18, 1909. Each dose consisted of 

 200 mg. of the crude poison, 300 mg. being a fatal quantity 

 for rabbits of the size used. 



When a fatal dose of the protein poison is administered 

 the temperature rapidly falls, but with smaller repeated 

 doses a continued fever results. The more nearly the dose 

 approaches the fatal amount the more speedily will the 



5-3.09 .'.-I 5-5 .-,-;! 5-7 5-8 .,.'.) 5-19 5-11 5-12 5-13 5-14 



+ FIRST INJECTION OF SERIES. 



5-15 5-10 :.-17 5-18 5-19 5-20 5-21 5-22 5-23 5-24 5-25 5-20 



+ LAST INJECTION OF 8FRIE8. 



FIG. 13. The production of continued fever in a rabbit by repeated 

 subcutaneous injections of the poisonous group from the typhoid bacillus. 



animal succumb. Death may be sudden and under a high 

 temperature, or it may be slow and preceded by a fall of 

 several degrees below the normal. From sublethal doses 

 of the poison, animals recover quickly and apparently, 

 completely. This seems to indicate that the poisonous 

 effects are quickly neutralized in the animal body, but we 

 are of the opinion that this neutralization is secured by 

 more or less chemical disintegration in the protein molecule 

 of certain cells in the body. The protein poison is acid to 

 litmus, and we have secured continued fever in rabbits by 

 repeated injections of either the acid solution or the same 



