PROTEIN FEVER 387 



each injection the temperature arose within from two to 

 four hours, and returned to normal during the evening, 

 and continued so until the next injection. With increase 

 in the size of the dose the tendency was to take the remittent 

 type, so that at no time of the day did the fall quite reach 

 the normal limit. 



Group VI. We have found some rabbits which do not 

 respond to the pyrogenic effect of intravenous injections 

 of egg-white until the size of the dose is reduced. On 

 receiving a new consignment of rabbits, we were surprised 

 to find that these animals did not develop fever on receiving 

 repeated doses of a dilution of egg-white (1 to 1) with salt 

 solution. The following illustrates our experience: 



No. 101. This animal, weighing about 2600 grams, was 

 treated with increasing doses of the dilution (1 to 1): 



Time. Dose in c.c. Temperature. 



9.00 A.M. 1 102.0 



10.00 2 100.4 



11.00 3 100.5 



12.00 4 100.2 



1.00 P.M. 5 100.0 



2.00 6 96.4 



3 . 00 Death 



The abdominal cavity was filled with bloody fluid. The 

 urine found in the bladder contained a small amount of 

 albumin. 



No. 102. Thinking that No. 101 was an individual 

 exception, No. 102 was treated with the same dilution: 



Time. Dose in c.c. Temperature. 



10.00 A.M. 1 101.2 



11.00 2 101.4 



12.00 3 101.5 



1.00 P.M. 4 101.5 



2.00 5 101.8 



3.00 6 101.3 



4.00 7 101.5 



4.45 Death 



