SPECIFIC FERMENTS OF THE CANCER CELL 423 



Fig. 29 illustrates daily counts following a single intra- 

 peritoneal injection of cells from a breast adenocarcinoma. 

 This is rather an extreme reaction, inasmuch as the pro- 

 portion of large mononuclear cells is increased from 6 per 

 cent, to 35, about 500 per cent. 



Fig. 30 shows a very slight reaction following the. injec- 

 tion of a breast-cancer residue which has almost lost its 

 activity. 



FIG. 26. Sheep injected with 0.5 c.c. sarcoma residue. 



Figs. 31, 33, and 34 illustrate rabbits giving the average 

 reactions. Fig. 32 represents the effect of giving an 

 intraperitoneal injection of 10 c.c. of breast-carcinoma 

 cell-emulsion into a rabbit sensitized to sarcoma vaccine, 

 the injection being given when the percentage of large 

 mononuclear cells was at its highest point. Death resulted 

 in from eight to ten hours. 



In order to ascertain just what bearing this change in 

 percentage of large mononuclear leukocytes had to the 

 formation of a specific ferment, several rabbits were sensi- 



