FIG. 49. CYTORYCTES VARIOLAE, GUARNIERI. 1, A cell from a section 

 of a smallpox lesion : three amoebulae are present in the cytoplasm 

 close to the nucleus ; 2, a cell containing an older amoebula in the 

 cytoplasm ; 3, a cell containing a large amoeboid parasite in the 

 cytoplasm ; 4, a cell containing an amoeboid parasite in process of 

 amoebula-formation, and, above, a round dense body, probably a 

 microgametocyte ; , a cell containing an amoeboid parasite in process 

 of gemmule-formation : some of the amoebulae are escaping into the 

 cytoplasm ; 6, a cell the nucleus of which contains five spores and 

 three secondary sporoblasts developed from spores : there is one 

 spore in the cytoplasm ; 7, a cell the nucleus of which contains 

 secondary sporoblasts ; 8, a cell the nucleus of which contains a 

 reticular sporoblast, with spores, some of which have escaped from 

 the meshwork ; 9, a cell the nucleus of which has been replaced by a 

 large sporoblast, from which some of the spores have escaped into 

 the cytoplasm. Copied from the coloured plates illustrating G. N. 

 Calkin's section of " Studies of the Pathology and on the Etiology of 

 Variola and of Vaccinia," published in the Journal of Medical Research, 

 1904. 



