SMALLPOX, SYPHILIS, CANCER, ETC. 177 



his later thought allows, having discovered in freshwater 

 protozoa a species of vegetable protist, which may be found 

 to play an important part in some human pathological 

 processes. Another organism, Lymphosporidium truttae, was 

 also discovered by Calkins (see Part I, pp. Ill to 115). 

 The mode of reproduction seen in Fig. 51, e, was the only 

 one found ; this organism also would appear to be a Plas- 

 somyxa. 



The stages of Karyoryctes described by Calkins corre- 

 spond only to the intranuclear stages of Cytoryctes variolae. 

 Is there another intracytoplasmic cycle in the same or another 

 animal, or even in man ? Among tumours goitre is associated 

 with certain water-courses, and in goitres intracytoplasmic 

 cell-inclusions resembling Cytoryctes variolae occur. 



Syphilis 



Parasitic forms occurring in Syphilis. In 1892 flagellates 

 were described by Doehle as they had been found by him in 

 the blood of patients suffering from syphilis, smallpox, 

 vaccinia, measles, and scarlet fever. 



My own first aim was to see whether the parasite of 

 syphilis conformed to the type Cytoryctes variolae. On the 

 3rd day after inoculation with the exudation of a chancre 

 I found in the corneal epithelial cells of a rabbit bodies 

 comparable to the early state of Cytoryctes variolae. 



Cell-infiltration by leucocytes and young tissue-cells 



obscured the view in my sections of chancres. At that time, 



12 



