82 INFLUENCES AFFECTING THE LEUCOCYTES 



cases of cancer of the ovary. The greatest numbers of eosins 

 have been found in cases of mixed celled leukemia. 



The eosins are diminished during severe muscular exertion, after 

 castration (Neusser), in the febrile stages of diseases having in- 

 flammatory leucocytosis, in the moribund state, in malignant 

 disease and generally after hemorrhage. 



BASOPHILIA 



The greatest numbers of mast cells recorded have been found 

 in mixed celled leukemia. Individual cases of increased mast cells 

 have been reported; but these cells are not constantly increased 

 in any particular condition so far as has been observed. 



OCCURRENCE OF MYELOCYTES 



Myelocytes have been observed in the largest numbers in mixed 

 celled leukemia in which from 20-60% of the leucocytes are finely 

 granular myelocytes. A small number of myelocytes may some- 

 times be found in cases of infectious diseases having a polynuclear 

 leucocytosis. The presence of the myelocytes indicates hyper- 

 plasia and hyperemia of the bone marrow. Sometimes after severe 

 mechanical disturbances of the circulation, as in uremia, asphyxia 

 and acute mania, a few myelocytes may be found in the circulating 

 blood. Ewing has observed a few myelocytes in ante-mortem 

 leucocytosis. They have also been found in some cases of second- 

 ary and of primary anemia. 



Eosinophilic myelocytes occur in greatest abundance in leu- 

 kemia, and have been observed rarely in a few other conditions, 

 myxedema (Mendel), v. Jaksch's anemia, in some infectious dis- 

 eases (Turk), pernicious malaria (Bignami). 



LEUCOPENIA (lIYPOLEUCOCYTOSIS) 



In leucopenia the several varieties of leucocytes are not neces- 

 sarily affected alike, very frequently some are lessened much more 

 than others. With the reduction in the total number there may 

 even be an increased number of some variety. Leucopenia occurs 

 in a variety of conditions, as fasting, malnutrition, after short hot 

 or prolonged cold baths, often during the initial stage of inflam- 

 matory and experimental leucocytosis, in many cases of anemia, 

 often in non-septic tuberculosis, and following the injection of 



