92 SPECIAL DISEASES OF THE BLOOD 



have been examined in this laboratory of lymphatic leukemia in 

 the common fowl. Warthin examined the blood of one of his 

 cases during the life of the fowl and found 450,000 red cells and 

 280,000 leucocytes, of which there were 1.5% small lymphocytes, 

 84.5% large lymphocytes, 11.5 polymorphonuclears "crystalloid 

 eosinophils, " 2% degenerating white cells and 0.5% mast cells. 



Ellermann and Bang have reported three cases of leukemia in 

 fowls. One of them they succeeded in transmitting to other fowls 

 by the inoculation of an emulsion of the organs, bone marrow, 

 liver and spleen. In some of the later transmissions they used 

 blood, in some an emulsion filtered to remove the cells. They 

 report transmitting the disease to six generations. In both the 

 spontaneous and the experimental cases they found the increase 

 in leucocytes to be in the "large mononuclears." Schmeisser also 

 has reported a case of spontaneous leukemia in a fowl which he was 

 able to transmit to other fowls, to the fifth generation. His ex- 

 perimental cases are reported to show an increase in leucocytes, 

 131,200 to 210,000, the majority (86%) of which were "large 

 mononuclears." Mitoses were common in these. The red cells 

 were lessened in number, in one case to 620,000. The hemoglobin 

 was diminished, often to 10 or 15 per cent, just before death. His 

 spontaneous case, from which the experimental cases developed, 

 differs from these in that the majority (52%) of the leucocytes, 

 which were in the proportion of 1: 1.3 red cells, are stated to 

 be "mononuclear myelocytes with eosinophilic granules." If 

 Schmeisser's interpretation is correct, his case is a new variety of 

 leukemia. 



PSEUDOLEUKEMIA (hODGKIn's DISEASE, LYMPHADENOMA 

 LYMPHOMA) 



This disease cannot be differentiated from lymphatic leukemia 

 anatomically or histologically if the blood be excepted. The 

 blood is practically normal except during the later stages when it 

 may show secondary anemia. A relative lymphocytosis often, 

 though not always, is found. The proportion of leucocytes to red 

 corpuscles is generally normal, though there is occasionally a 

 moderate increase in the number of leucocytes. 



There is marked enlargement of the lymph glands and lymph 



