GLANDERS 109 



The number of red corpuscles is high in most of his cases, highest 

 in the cases with the highest leucocyte count. Probably the 

 polycythemia in these cases was due to anhydremia, but not 

 enough of the clinical condition of the cases is given to enable one 

 to tell. 



There is a polynuclear leucocytosis in active cases. Mild cases 

 may have no increase in the leucocytes. Other varieties of leu- 

 cocytes are usually not increased. The more severe the case the 

 greater is the increase in the polymorphonuclears. In severe, 

 actively progressive cases, the eosinophiles may be absent or 

 present in very much smaller number. The condition is an in- 

 flammatory leucocytosis. In non-clinical cases there may be no 

 increase in the number of leucocytes. Macchia found the leu- 

 cocytes increased twenty four hours after inoculating an ass. The 

 third day there were 17,500 per cmm., the sixth day 31,250, the 

 eighth day 34,792, the ninth day 60,000. The fourteenth day the 

 ass died of acute glanders. Mikrukow examined glandered horses 

 and cats and found that the leucocytes increased till toward the 

 end of the disease when they were at least three times the normal 

 number. Noniewicz examined three glandered horses and found 

 the leucocytes increased, in a case of chrome farcy in the propor- 

 tion of one leucocyte to twenty red corpuscles and in a case of 

 chronic glanders, early stage, in the proportion of one to thirty. 

 Prus found that the leucocytes were increased in glandered horses 

 to 20,000-60,000 and that the polymorphonuclears were in greater 

 than normal numbers and percentages. He obtained the following 

 percentages: eosins 3 per cent., mast cells 2 per cent., basophile 

 cells 5 per cent., neutrophiles 75 per cent., small lymphocytes 10 

 per cent., large lymphocytes 2 per cent, and transitional cells 3 

 per cent. Bidault found a polynuclear leucocytosis in horses. 

 Mielke examined 19 glandered horses and found a polynuclear 

 leucocytosis in each case. The leucocytes varied from 14,000 to 

 48,200 per cmm. The polymorphs ranged from 11,802 to 42,271 

 per cmm. 



Burnett and Pearce found a polynuclear leucocytosis in severe 

 cases of glanders in horses. Mild cases did not have an increase 

 in the leucocytes. A summary of Burnett and Pearce's cases is 

 given in tables XXXI and XXXII. Christot and Kiener report a 

 leucocytosis in acute glanders in man, horse and guinea pig, and 



