128 INFECTIOUS DISEASES DUE TO PROTOZOA 



Dog XI 



The blood is pale as if diluted with water. Coagulation is 

 slower than in normal blood. The serum is tinted with Hb. 

 The red corpuscles present considerable changes, some are larger 

 (from one-third to two-thirds) and paler than normal; some are 

 smaller than normal. At the time parasites appeared erythro- 

 blasts were also found present (Wright). Erythroblasts in some 

 cases are present in large numbers. 



The leucocytes are usually much increased. Nocard found 

 as high as 40,000. Wright found nearly 52,000 in one and 60,000 

 in a second case. In one dog Wright found that the leucocytes 

 dropped gradually from 20,000 on the 15th day to 10,000 on the 

 22d day. The increase, according to Nocard and Motas, is nearly 

 always in the polymorphonuclears. In Wright's case both poly- 

 morphonuclears and mononuclears were increased. 



In the chronic form of the disease there is marked anemia, the 

 red corpuscles decreasing to about two millions. In one of Nocard 

 and Motas' cases they fell to 1,200,000. The return to normal is 

 very slow. They are scarcely returned to normal before two or 

 three months (Nocard and Motas). As recovery progresses the 

 number of red corpuscles increases; erythroblasts become rare. 

 The Hb suffers much less than the red corpuscles. In one of 

 Nocard and Motas' cases with only 2,700,000 red corpuscles there 

 was 9J^% Hb. The changes in the size and staining of red corpuscles 

 are more marked than in the acute form. Some corpuscles are 

 two or three times the normal diameter and stain less deeply; 

 Many erythroblasts are present at the beginning of the decrease 

 in red corpuscles. 



The Dumber of leucocytes is increased, ordinarily from 15-30,000. 

 Nocard and Motas record one case where they reached 54,000. 

 The leukocytosis involves polynuclears and mononuclears equally. 



