BABESIA MUTANS, THEILER 131 



infrequently larger than the non-infected corpuscles. Later when 

 the anemia is marked very many relatively large, pale corpuscles 

 are found (Theiler). Williams found variation in the size and 

 shape of red corpuscles, (megalocytes, microcytes, poikilocytes) 

 and polychromatophilia and an increase of mononuclear and 

 polymorphonuclear leucocytes; in some smears also a marked 

 increase in the eosinophiles. Counts were not given. 



OVINE PIROPLASMOSIS (CARCEAG) 



Babesia ovis, Starcovici, discovered by Babes in 1892, is very 

 similar to Babesia bigemina. The form of the parasite is round 

 or pyriform. It is not rare to find two to four in the same red 

 corpuscle. The liver seems to be the principal depot of the para- 

 sites, which occur within red corpuscles and free (Motas). Divid- 

 ing forms are frequent in the capillaries of the liver. The injection 

 of a large quantity of virulent blood into cattle, goats, dogs, cats 

 and rabbits was without effect (Motas). 



Complete examinations are not recorded. The number of red 

 corpuscles falls from eight or nine millions to four millions or less. 

 There is a marked diminution in the amount of hemoglobin, from 

 13 and 14 grams per 100 cc. to seven or eight grams per cubic 

 centimeter and a lessened coagulability (Motas). The red cor- 

 puscles vary greatly in size (Bonome). 



BABESIA MUTANS, THEILER 



Theiler has recently described another species of Babesia in the 

 blood of cattle in South Africa. He named the parasite causing 

 it Piroplasma mutans. The organism is found, though never 

 present in large numbers, in the peripheral blood of the affected 

 animals. In the cases observed by Theiler, B. bigemina has also 

 been present. The disease is inoculable, thus differing from East 

 coast fever. Theiler inoculated 15 calves with the blood of cattle 

 immune to red water and obtained reactions with small organisms 

 in the blood from the 25th to the 41st day after inoculation, be- 

 tween the secondary and tertiary reactions due to B. bigemina. 

 The parasites were present in the blood in small numbers. The 

 importance of this disease is that it is liable to be mistaken for 



